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KMID : 0861019980130020129
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Korea Journal of Herbology
1998 Volume.13 No. 2 p.129 ~ p.135
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Effect of Sipjeon-Daebo-Tang on Thymocytes of Anti-tumor Drugs Administered Mice
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金大根/Kim, Dae-Keun
殷載淳/全薰/宋正模/Eun, Jae-Soon/Jeon, Hoon/Song, Jeong-Mo
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Abstract
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The purpose of this research was to investigate effects of Sipjeon-Daebo-Tang(SDT) on thymocytes of anti-tumor drugs administered mice. DNA fragmentation, mitochondrial transmembrane potential and subpopulation were tested using a flow cytometry. and the cell viability was tested using a MTT assay. Etoposide, vincristine and doxorubicin enhanced DNA fragmentation and reduced mitochondrial transmembrane potential of thymocytes, but SDT recoverd the action of vincristine and doxorubicin. Etoposide or vincristine decreased the population of CD4 single positive cell in thymocytes, but SDT enhanced the population of CD4+ single positive cell. Etoposide, vincristine and doxorubicin decreased the cell viability of thymocytes, but SDT enhanced the cell viability. These results suggest that SDT has a regulative function of thymocytes in anti-tumor drugs administered mice.
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KEYWORD
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